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Researchers from the National Human Genome South Research Center, the First Affiliated Hospital of Xinjiang Medical University and Fudan University have successfully drawn a sketch of the genome sequence of Echinococcus granulosus. This research provides some new insights into the interaction of this parasite with the host, nutrient absorption, strobilization, reproduction, immune escape and maturation mechanisms, and provides us with a platform to promote the development of new Hydatidosis treatment and control interventions.
Researchers from the National Human Genome South Research Center, the First Affiliated Hospital of Xinjiang Medical University and Fudan University have successfully drawn a draft genome sequence of Echinococcus granulosus. This research provides some new insights into the interaction of this parasite with the host, nutrient absorption, strobilization, reproduction, immune escape and maturation mechanisms, and provides us with a platform to promote the development of new Hydatidosis treatment and control interventions. Related results were published in the journal Nature Genetics on September 8. Academician Zhu Chen and researcher Shengyue Wang of the Southern Research Center for Human Genome, Dr. Zhou Zhou of Fudan University, Professor Donald P McManus of the QIMR Berghofer Medical Research Institute of Australia, and the First Affiliated of Xinjiang Medical University Professor Wenbao Zhang of the hospital is the co-corresponding author of this paper.
Echinococcus granulosus belongs to the genus Zelidae and Echinococcus. It is an important parasite of animal origin. At least 50 million people worldwide are infected with this parasite. Its life cycle involves two mammals, the intermediate host of which is usually domestic or wild ungulates (human beings are its occasional intermediate hosts), and dogs are its ultimate hosts. The larval stage can cause a serious zoonotic disease called hydatidosis or echinococcosis. At present, as many as 3 million people are infected with Echinococcus granulosus, and in some regions 10% of the population have detected hydatid cysts through abdominal ultrasound and chest X-ray photography.
Echinococcus granulosus itself has no intestines, circulation or respiratory organs. The diploid eggs produced by hermaphrodite can develop into six-hooked larvae. A unique feature of the larvae in the hydatid cysts (protohead section) is the ability to develop bi-directionally into adult worms in the gastrointestinal tract of dogs, or to form secondary hydatid cysts in the intermediate host (human). trigger. Another distinguishing feature of Echinococcus granulosus is its ability to infect and adapt to a large number of mammalian species, making it an intermediate host for them, which has contributed to their widespread global distribution.
In this article, the researchers reported that the Echinococcus granulosus genome was sequenced and analyzed to obtain a draft genome sequence of the parasite, which contains 151.6 Mb of sequence and 11,325 genes. Echinococcus granulosus contains 9 pairs of chromosomes. It is one of the first tapeworm genomes to be sequenced. It is the high-quality Echinococcus multilocularis genome published in the Nature magazine by Wellcome Trust Gene Science Park in the United Kingdom. Provided a supplement.
By comparing the genome sequences of other Taenia species, the researchers revealed that Echinococcus granulosus has acquired a series of genes including the EgAgB family. Echinococcus granulosus interferes with and changes the host immune response by secreting the products of these genes. . The researchers found that genes in the bile salt signaling pathway may control the bidirectional development of Echinococcus granulosus, and the sequence difference of the calcium channel subunit EgCavβ1 may be related to its sensitivity to praziquantel antiparasitic drugs.
The new research provides some new insights into the biology, development, differentiation, evolution, and host interaction of Echinococcus granulosus, and identifies some drugs and vaccine targets, which may promote the development of hydatid treatment and control. New intervention tool.
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