With the rapid development of molecular biology and biochemical technology, peptide research has made an amazing leap. It has been found that there are tens of thousands of kinds of polypeptides in living organisms, and all cells can synthesize polypeptides. At the same time, almost all cells are regulated by peptides, which involve various fields such as hormones, nerves, cell growth and reproduction. In fact, the development and application of peptide drugs have gone out of the scientists' labs and become a reality, and exert their unique effects. For example, neurotensin (NT) can lower blood pressure and have a contractive effect on the intestine and uterus; thyrotropin-releasing hormone (TRH) is a polypeptide that can promote maternal milk secretion; a polypeptide that can treat diabetes, gastric ulcer, pancreatitis It is a cyclic 14-peptide; oxytocin commonly used in clinic is a polypeptide; glycopeptide has been used in China and Japan recently to assist in the treatment of tumors, its mechanism of action is to activate the lymphatic system and so on. The medical protein chip (peptide chip) developed using peptide technology is only the size of a fingernail. Antigen molecules related to nephritis, gastric ulcer and gastric cancer are placed. As long as the chip reader can be used to detect the functional status and mutation of the disease. The wide application of peptide chips has triggered a technological revolution in the medical clinical testing industry.
Since Merrifield successfully developed the SPPS method in 1963, after continuous improvement and improvement, this method has become a common technology in the synthesis of peptides and proteins. Many common units can pass ready-made peptides. Synthesize the scheme. For novices, understanding the principles of certain peptide synthesis is good for understanding the process of peptide synthesis and eliminating the problems encountered in the synthesis. In simple terms, the most basic programmed peptide synthesis process is nothing more than resin swelling, deprotection, coupling, re-deprotection, re-coupling ... Other special synthesis is established on this basis. For novices in peptide synthesis, there are several misunderstandings that need attention:
Misunderstanding of peptide synthesis 1: The longer the synthesis time, the better. The efficiency of peptide synthesis has been explored and optimized for many years. The synthesis efficiency of each step can reach more than 99% in a short time. The excessively long reaction time has a very limited increase in the positive reaction yield, but greatly increases the occurrence of side reactions. Probability, so long reaction time is not good.
Peptide Synthesis Misunderstanding 2: Universal peptide-cutting reagent. Most peptides can be cut from the resin with a combination of peptide-cutting reagents. For amino acids with special side chain protection, this combination often needs to be adjusted, and for peptide sequences without side chain protection, it is necessary to add A solution of 98% TFA and 2% water can be completed. The combination of peptide-cutting reagents should be used flexibly.
Misunderstanding of peptide synthesis 3: amino acid side chain protection is the same. Amino acids with active side chains need to be protected during synthesis. Depending on the side chain, there are different choices for protecting groups. Choosing the appropriate protecting group can effectively reduce the difficulty of synthesis.
Cali-Bio has the most advanced technology and process in the process of peptide synthesis. It has successfully synthesized tens of thousands of high-purity peptides for many scientific research institutions, colleges and biological companies in the United States, which are used in antibody preparation and drug development. And the development of peptide vaccines and other fields. Cimejet introduced Cali-Bio's peptide synthesis service to China, and combined with China's national conditions, it aims to provide Chinese customers with special services for the quality of peptide synthesis abroad and enjoy domestic synthesis prices. In order to give back to our customers' support for Simex products and services, we now provide a 15% discount on Cali-Bio peptide synthesis services in the United States! For details, please click: Peptide Synthesis-Cali-Bio Peptide Synthesis Service in USA
If you are interested in the above peptide synthesis services, please contact / 9569/8795/4237 to Ximeijie Technology Co., Ltd. (Shanghai please / 63599872 to Ximeijie Shanghai Branch) to inquire about the related custom synthesis services, we will provide you with After completing the order, Ximeijie will do more for you!
Progress and misunderstanding of peptide synthesis technology
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