Guide
"N-acetylcysteine ​​(NAC)" is an inexpensive drug commonly used to relieve the symptoms of colds. In a recent study, it has been found to have enormous potential: it can treat cancer through "starvation" cancer. Cells prevent their growth and spread.
On November 10th, the journal "Seminars in Oncology" published an article online, revealing the new results of this "new drug use".
NAC
NAC is an over-the-counter and dietary supplement that is commonly used to relieve colds and flu symptoms such as coughing, wheezing and runny nose. In addition, NAC can also be applied to acetaminophen excess, cystic fibrosis, and chronic obstructive pulmonary disease. As a general medicine, its price is relatively cheap, a box of 10s NAC film is priced at more than 20 yuan.
NAC is antioxidant, which means it can reduce cell damage caused by oxidative stress. Previous studies have shown that tumor stromal cells have high levels of oxidative stress, especially breast cancer tumors. When tumor stromal cells are exposed to oxidative stress, they release lactic acid and other "nutrients" that promote tumor growth.
With these two points in mind, the author of the article, Federica Sotgia of the University of Salford and the team speculate that the antioxidant properties of NAC may "starve" cancer cells.
Encouraging results
To validate the conjecture, the research team recruited 12 women with stage 0 or stage 1 breast cancer for related trials. Within 3 weeks of the patient's diagnosis from surgery to surgery, they will receive NAC treatment, including weekly intravenous injections (150 mg/kg each), and daily (except for those on the intravenous day). Secondary NAC tablets (600 mg per dose).
Before and after surgery, the patient's tumor tissue will undergo biopsy analysis, focusing on three markers (related to cancer progression and poor overall survival): MCT4, CAV1 and Ki67. The results showed that the level of Ki67 was reduced by 25%, while the level of MCT4 was reduced by 80%.
This means that NAC can inhibit the expression of MCT4 protein in a non-toxic manner, thereby preventing the growth and division of cancer cells.
The Sotgia team hopes that this latest study will “re-energize†the cheap drugs that the FDA has approved to bring new options to cancer treatment.
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